TWAIN issues with CanoScan Lide scanners
Most TWAIN issues with LIDE/CANOSCAN scanners can be solved by performing a clean installation.
- Unplug the USB cable from the scanner and run the DELDRV.exe (uninstall utility) program from the CD, or download it from the Canon website.
- Cut the power or turn off your DSL/CABLE internet modem.
- Unhide your system folders by RIGHT click on the START button, then LEFT click EXPLORE. Click on TOOLS on top of window and select FOLDER OPTIONS. Click on the VIEW tap, then click on SHOW HIDDEN FILES AND FOLDERS. Hit OK and close out of everything.
- Click on START and select RUN. In the RUN window, type MSCONFIG. System Configuration Utility will pop up. Click on SELECTIVE STARTUP, then take the check out of LOAD STARTUP ITEMS. Click APPLY and then CLOSE and restart computer.
- Run the install from the CD as normal and Restart again. Once computer is back up, THEN PLUG USB CABLE BACK IN. Perform a scan.
- Go back to MSCONFIG and click on NORMAL STARTUP, APPLY, CLOSE, and restart once more. You will then be able to reconnect to your internet modem.

WIN XP does not like having two USB scanners/software loaded at the same time. Microsoft has an article about it. You MUST remove/uninstall previously loaded scanner software. Also check the TWAIN_32 sub-directory in the WINDOWS/WINNT directory and make sure that only the CNQxxx folder and WIATWAIN.DS file are the only things in there. If you already have another imaging device installed (webcam, digital camera) you may have to uninstall those before the scanner software has been loaded in, then reinstall the other devices.
This solved my problem with CanoScan Lide25 which continuously gave this error before “Unable to open TWAIN source please check connection then re-start toolbox”
I have found a working solution.
Try this out:
http://weblogs.asp.net/jeffwids/arch…in-source.aspx
It certainly solved my problems!
You are so wrong this does not work. The issue is that Vista does not like two Twain devices installed at the same time. Remove the old one and it will work. Worked for me, and the suggestions above are just nonsence.
I am not completely wrong as this is an old post related to Twain devices issue specifically in Win XP, and this was how I had solved it. May be Vista does not have this issue anymore and removing the old one worked for you but that does not mean my suggestions are nonsense! Anyways thanks for commenting.
OMG you don’t understand anything. Is the un-installing of the previous devices not going into MSCONFIG that fixed the problem. This is most likely going to crash your PC if you don’t know what you are doing. Why don’t you go and hack some registry items while you are messing up your PC. Stop giving bad advice.
OMG you could have 20 years experience in the industry and your points could be very valid but still doesnt change the fact your a d***, it works so zip it. Sometimes with IT the strangest things make stuff work so dont dish out crap advise. My advise read up on what your doing before you do it, get a understanding of what does what BEFORE you change it, always create a backup or restore point BEFORE you try anything.
(yeah i know it doesnt matter a year later but my point stands)
Priyanka, great stuff here. Just wanted to let you know a lot of people have been experiencing the same issue, and sharing their solutions on my blog — http://blog.dylanmullins.com/?p=254
Feel free to remove the link if you don’t allow that sort of thing. Just trying to help anyone else who is having these issues.
Its really nice that we can help each other with real solutions by sharing the issues over Internet.
That’s really interesting I have had lots of people asking me about this same problem and didn’t know what to do so thanks for help.